Abstract: 　IKAROS family zinc finger 1 （IKZF1） gene encoding a zinc finger transcription factor IKAROS plays an important role in the regulation of B lymphoid cell differentiation and proliferation. IKZF1 is a clinical tumor suppressive factor. Deletion of IKZF1 results in either haploinsufficiency or dominating negative for IKAROS that contributes to the development of B-cell acute lymphoblastic leukemia (B-ALL), associated with an poor prognosis. Study of IKZF1 may lead to identifying new risk stratification molecular indicator for B-ALL for a better guidance to individualized therapy.